Italian Journal of Pediatrics

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Open Access Letter to the Editor

Neonatal diabetes mellitus due to pancreatic agenesis and pervasive developmental disorder

Alessandro Giannattasio1*, Maria Pintaudi2, Maria M Mancardi2, Francesca M Battaglia2, Edvige Veneselli2, Renata Lorini1 and Giuseppe d'Annunzio1

Author Affiliations

1 Department of Pediatrics, University of Genova, Giannina Gaslini Institute, Genova, Italy

2 O.U. of Child Neuropsychiatry, Giannina Gaslini Institute, Genova, Italy

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Italian Journal of Pediatrics 2009, 35:23 doi:10.1186/1824-7288-35-23

Published: 31 July 2009

Abstract

Recent studies suggested a link between type 1 diabetes mellitus and pervasive developmental disorder. Moreover, permanent neonatal diabetes mellitus due to pancreatic agenesis can be associated with neurological deficit involving cerebellar functions, but no association with pervasive developmental disorder has been described so far. Clinical and neuropsychological evaluation of a child with pancreatic agenesis, mental retardation and pervasive developmental disorder is reported.