Research
Immune-related disorders in families of children with inflammatory bowel disease - A prospective cohort study
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* Corresponding author: Wael El-Matary welmatary@yahoo.com
1 Department of Pediatrics, Stollery Children's Hospital, Faculty of Medicine, University of Alberta, Edmonton, Canada
2 Section of Pediatric Gastroenterology, Department of Pediatrics, University of Manitoba, Winnipeg, Canada
Italian Journal of Pediatrics 2011, 37:49 doi:10.1186/1824-7288-37-49
Published: 4 October 2011Abstract
Background
The aim of this paper was to examine the prevalence of immune-related disorders in families of children with inflammatory bowel disease (IBD) compared to those without IBD.
Methods
Children ≤18 years of age presenting to the IBD clinic between September 2007 and August 2009 with an established diagnosis of IBD were recruited. Age and sex matched controls without IBD were recruited. The study was a single-centre prospective cohort study. Outcome measures were prevalence of immune-based/inflammatory diseases in families of both patients and controls.
Results
One hundred and eight children in each group were recruited. Asthma was the most frequently reported disease in families of the IBD patients (52.8%) and controls (46.3%). The prevalence of IBD in families of IBD patients was significantly higher than in those without IBD (OR 2.03, 95% CI 1.04-3.95).
Conclusions
The prevalence of immune-based disorders, as a group, in families of children with IBD was not significantly higher when compared to children without IBD.