Italian Journal of Pediatrics

tracked for impact factor
Search for
Advanced search
Italian Journal of Pediatrics
Tools
Share this article
Open Access Case report

Castleman's disease in childhood: report of three cases and review of the literature

Piero Farruggia1, Antonino Trizzino1, Nunzia Scibetta2, Giovanni Cecchetto3, Patrizia Guerrieri4, Emanuele SG D'Amore5 and Paolo D'Angelo1*

Author Affiliations

1 Unit of Pediatric Hematology and Oncology, "G. Di Cristina" Children's Hospital, A.R.N.A.S., Palermo, Italy

2 Unit of Pathology, "Civico e Benfratelli" Hospital, A.R.N.A.S., Palermo, Italy

3 Pediatric Surgery Department, University of Padua, Padua, Italy

4 Unit of Oncological Radiotherapy, "Civico e Benfratelli" Hospital, A.R.N.A.S., Palermo, Italy

5 Unit of Pathology, San Bortolo Hospital, Vicenza, Italy

For all author emails, please log on.

Italian Journal of Pediatrics 2011, 37:50 doi:10.1186/1824-7288-37-50

Published: 20 October 2011

Abstract

Castleman's disease (CD) is a rare, localized or generalized, lymphoproliferative disorder with a frequent mediastinal location, but possible in any lymph node or extra nodal site. It usually appears in young adults whilst it rarely occurs in childhood. There are only about 100 pediatric cases published, five of them in Italy. We report 3 cases of localized Castleman's disease, investigated in our Department in a 3 years period and reviewed the literature.

Keywords:
Castleman's disease; childhood; differential diagnosis; histological subgroups; outcome