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Open Access Commentary

Hashimoto's thyroiditis in childhood: presentation modes and evolution over time

Filippo De Luca*, Simona Santucci, Domenico Corica, Elda Pitrolo, Marika Romeo and Tommaso Aversa

Author Affiliations

Department of Pediatrics, University of Messina, Padiglione NI Policlinico Universitario, Via Consolare Valeria, 98125, Messina, Italy

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Italian Journal of Pediatrics 2013, 39:8  doi:10.1186/1824-7288-39-8

Published: 30 January 2013

Abstract

Aim of this survey is to report the most recent views about Hashimoto’s thyroiditis (HT) natural history according to the different presentations. In children presenting with either euthyroidism or subclinical hypothyroidism HT spontaneous course is frequently characterized by a trend towards deterioration of thyroid function, whereas in those presenting with overt hyperthyroidism a definitive resolution of hyperthyroid phase is to be expected. Another possible even though unusual outcome of HT is the conversion to Graves’ disease.

Keywords:
Autoimmune thyroid disease; Hashitoxicosis; Subclinical hypothyroidism; Thyroid autoantibodies